Gandou decoction (GDD) is a classic prescription for the treatment of hepatolenticular degeneration (HLD) in China; however. the liver-protecting mechanism of this prescription needs further evaluation. In the present study. we explored the protective mechanisms of GDD in a copper-laden HLD model using integrated pharmacology and cellular metabolomics in vitro. https://parisnaturalfoodes.shop/product-category/5-5-mahogany/